Samantha Kendrick

Federal Grant PI

Associate Professor

University of Arkansas for Medical Sciences

faculty

Biochemistry & Molecular Biology, College of Medicine

16 h-index 101 pubs 1,759 cited

Research Areas

Cancer-related molecular mechanisms research Herpesvirus Infections and Treatments DNA and Nucleic Acid Chemistry Cancer Treatment and Pharmacology Viral-associated cancers and disorders Receptor Mechanisms and Signaling Computational Drug Discovery Methods

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Samantha Kendrick's research focuses on understanding the molecular mechanisms underlying cancer, with a particular emphasis on identifying novel therapeutic targets and strategies. Her work investigates the role of specific DNA structures, such as G-quadruplexes and i-motifs, in oncogenic pathways and their potential as targets for drug development. She has published research on targeting these structures in genes like MYD88 and the CARD11 oncogene promoter.

Kendrick's laboratory also explores the therapeutic potential of natural compounds and bifunctional inhibitors against various cancers, including small-cell lung cancer and virus-associated lymphomas. Her recent publications detail the identification of compounds targeting BCAT1 and NEK2, and the development of HDACs/BRD4 inhibitors for lymphoma treatment. Her work has also examined the anti-COVID-19 drug Remdesivir's role in promoting oncogenic herpesvirus reactivation, highlighting the complex interplay between viral infections and cancer.

As a Principal Investigator, Kendrick has received federal funding for her cancer research, including a grant from the NIH/National Cancer Institute. She actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Ying-Zhi Xu, Mason McCrury, Kennith Swafford, and Baku Acharya, with whom she has co-authored numerous publications. Her scholarship metrics include an h-index of 16, over 100 total publications, and nearly 1,800 total citations.

Metrics

h-index: 16
Publications: 101
Citations: 1,759

Selected Publications

G-quadruplex and i-motif DNA structures form in the promoter of the key innate immune adaptor MYD88 (2025) DOI
Oncolytic strategy using new bifunctional HDACs/BRD4 inhibitors against virus-associated lymphomas (2023) DOI
Targeting a Novel G-Quadruplex in the CARD11 Oncogene Promoter with Naptho(2,1-b)furan-1-ethanol,2-nitro- Requires the Nitro Group (2022) DOI
Identification of natural compounds tubercidin and lycorine HCl against small‐cell lung cancer and BCAT1 as a therapeutic target (2022) DOI
The Anti-COVID-19 Drug Remdesivir Promotes Oncogenic Herpesvirus Reactivation through Regulation of Intracellular Signaling Pathways (2022) DOI
Development of Humanized Diffuse Large B-Cell Lymphoma Mouse Models (2021) DOI
Clinical implications of loss of bone marrow minimal residual disease negativity in multiple myeloma (2021) DOI
Concomitant Deletion of Short Arm (del 1p) and Amplification or Gain (1q21) of Chromosome 1 By Fluorescence in Situ Hybridization (FISH) Is Associated with Poor Clinical Outcome (2021) DOI
Persistent bone marrow minimal residual disease as a “high‐risk” disease feature in multiple myeloma (2021) DOI
The i-Motif as a Molecular Target: More Than a Complementary DNA Secondary Structure (2021) DOI

Federal Grants 2 $1,220,115 total

NIH/National Cancer Institute Contact PI Sep 2020 - Aug 2026

Partnership in Cancer Research (PCAR)

National Cancer Institute $120,115 R25

NSF Co-PI

Replication of G-quadruplex DNA by translesion polymerases

Cross-BIO Activities, Genetic Mechanisms $1,100,000

Grants & Funding

Targeting unique DNA structures to repress oncogenic signaling in lymphoma DoD Principal Investigator
No FP attached UAMS ACHRI Flow Through Principal Investigator
Targeting unique DNA structures to repress oncogenic signaling in lymphoma US Department of Defense Principal Investigator
Targeting unique DNA structures to repress oncogenic signaling in lymphoma US Department of Defense Principal Investigator
Impact of DNA topology on facilitating mutational events in lymphoma American Cancer Society, Inc. Principal Investigator
Impact of DNA topology on facilitating mutational events in lymphoma American Cancer Society, Inc. Principal Investigator
Seeds of Science Pilot award UAMS Internal Research Awards Principal Investigator
Targeting oncogenic regulation through unique DNA structures in lymphoma NIH/NIGMS Principal Investigator