Sydnye L. Shuttleworth

OverviewAI-generated summary

Sydnye L. Shuttleworth's research focuses on understanding molecular mechanisms in disease, particularly in the context of cancer and immune responses. Her work has investigated therapeutic targets and regulators of oncogenic pathways in lymphoma, as evidenced by her publication on a bifunctional inhibitor targeting NEK2. Shuttleworth also studies T cell exhaustion, exploring its modulation of the DNA damage response and the role of specific proteins like PCK2 in T cell metabolic plasticity within glioblastoma.

Her federally funded work, supported by a grant from the NIH/National Cancer Institute, aims to leverage the E3 ligase RNF166 to prevent T cell exhaustion in solid tumors. Shuttleworth collaborates with researchers at the University of Arkansas for Medical Sciences, including Vijay Patel, Ying-Zhi Xu, Mason McCrury, and Kennith Swafford, with whom she shares multiple publications, indicating a collaborative research environment.

With a h-index of 2 and over 70 publications, Shuttleworth's scholarly output demonstrates consistent engagement with research in molecular biology and immunology. Her recent publications highlight a commitment to exploring novel therapeutic strategies and fundamental biological processes relevant to cancer and immune system function.

Metrics

• h-index: 2
• Publications: 72
• Citations: 41