Paul C. Howard Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

49 h-index 202 pubs 7,479 cited

Research Areas

Pharmacological Effects and Toxicity Studies Carcinogens and Genotoxicity Assessment Health and Medical Research Impacts Genomics and Rare Diseases SARS-CoV-2 and COVID-19 Research Advancing alternative methods to reduce animal testing

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OverviewAI-generated summary

Paul C. Howard's research focuses on toxicological studies, particularly investigating the effects of substances like NNK (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) in Sprague-Dawley rats. His work includes detailed toxicokinetic and genotoxicity assessments following various exposure routes, such as nose-only inhalation, intraperitoneal injection, and oral gavage. He has also examined the pharmacokinetics of nicotine and its metabolites under similar exposure conditions.

Beyond direct toxicological analysis, Howard has contributed to discussions on improving drug development processes, advocating for data sharing to benefit rare disease research. His recent publications also touch upon advancing alternative methods to reduce animal testing and exploring the psychological impacts of health crises, such as the COVID-19 pandemic, on young individuals with autoimmune conditions.

Howard has a substantial publication record with 202 total publications and 7,479 citations, reflected in his h-index of 49. He is recognized as a highly cited researcher. Key collaborators include Matthew Bryant, Sherry M. Lewis, Shu-Chieh Hu, and Hyun-Ki Kang, all from the National Center for Toxicological Research, with whom he has co-authored four publications each.

Metrics

  • h-index: 49
  • Publications: 202
  • Citations: 7,479

Selected Publications

  • Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024) DOI
  • 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021) DOI
  • 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021) DOI
  • Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021) DOI

Collaborators

Researchers in the database who share publications

Matthew Bryant National Center for Toxicological Research 4 shared publications Sherry M. Lewis National Center for Toxicological Research 4 shared publications Shu-Chieh Hu National Center for Toxicological Research 4 shared publications Hyun-Ki Kang National Center for Toxicological Research 4 shared publications Seonggi Min National Center for Toxicological Research 3 shared publications Dong-Jin Yang National Center for Toxicological Research 3 shared publications Raúl Trbojevich National Center for Toxicological Research 3 shared publications Mason G. Pearce National Center for Toxicological Research 3 shared publications

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