Matthew Bryant Source Confirmed
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Supervisory Toxicologist
National Center for Toxicological Research
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Biography and Research Information
OverviewAI-generated summary
Matthew Bryant's research focuses on evaluating the toxicity of various substances using in vitro and in vivo models. His work investigates the genotoxic potential of compounds like luteolin and nitrosamine impurities, often employing human lymphoblastoid TK6 cells engineered to express specific cytochrome P450 enzymes. Bryant also studies the integration of transcriptome analysis with pathophysiological endpoints to assess the toxicity of complex mixtures, such as cigarette smoke, in human airway tissue models.
His research extends to examining the pharmacokinetic profiles and toxicological effects of substances like NNK and nicotine in Sprague-Dawley rats, utilizing different exposure routes including inhalation, oral gavage, and injection. Bryant also investigates the involvement of hepatic cytochrome P450s in the cytotoxicity of pharmaceutical agents like lapatinib and the toxicity of aerosols such as ortho-phthalaldehyde in airway tissue models.
With 94 total publications and an h-index of 35, Bryant is recognized as a highly cited researcher. He maintains collaborations with several colleagues at the National Center for Toxicological Research, including Xiaobo He, Nan Mei, Qiangen Wu, and Robert H. Heflich, with whom he shares multiple publications. Bryant leads a research group and maintains an active laboratory website.
Metrics
- h-index: 35
- Publications: 94
- Citations: 3,771
Selected Publications
- Mechanistic study of pexidartinib-induced toxicity in human hepatic cells (2025) DOI
- Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025) DOI
- An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024) DOI
- Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024) DOI
- CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024) DOI
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024) DOI
- Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023) DOI
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023) DOI
- Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023) DOI
- Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022) DOI
- In vivo pharmacokinetic analyses of placental transfer of three drugs of different physicochemical properties in pregnant rats (2022) DOI
- 90-day nose-only inhalation toxicity study of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Sprague-Dawley rats (2021) DOI
- Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021) DOI
- 14-Day Nose-Only Inhalation Toxicity and Haber’s Rule Study of NNK in Sprague-Dawley Rats (2021) DOI
- Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021) DOI
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