Gonçalo Gamboa da Costa Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

31 h-index 98 pubs 2,753 cited

Research Areas

Pharmacological Effects and Toxicity Studies Diet and metabolism studies Drug-Induced Hepatotoxicity and Protection Bone health and treatments Carcinogens and Genotoxicity Assessment Metabolomics and Mass Spectrometry Studies

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Research Group

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OverviewAI-generated summary

Gonçalo Gamboa da Costa's research focuses on toxicological evaluations of various substances and their effects on biological systems, particularly in preclinical models. His work includes investigating the toxicity of high-molecular-weight polyethylene glycols and brominated vegetable oil in Sprague Dawley rats. He has also studied the effects of urinary pH on the renal toxicity of melamine and cyanuric acid and the impact of serum and compound preparation methods on delayed repolarization evaluations using human induced pluripotent stem cell-derived cardiomyocytes.

Further research by Gamboa da Costa examines the development of preclinical models for liver injury, such as a model of severe nonalcoholic steatohepatitis (NASH)-like liver injury induced by chronic high-fat and high-sucrose diet in mice. His investigations extend to the effects of coadministrations on bone health, as seen in his study on black cohosh extract and risedronate in an ovariectomized rat model. He also participates in discussions regarding animal microphysiological systems and the 3Rs (Replacement, Reduction, Refinement) in drug development, contributing to industry workshops.

Gamboa da Costa has a significant publication record, with 98 total publications and 2,753 citations, contributing to a h-index of 31. He is recognized as a high-impact researcher. His key collaborators at the National Center for Toxicological Research include Frederick A. Beland, Michelle M. Vanlandingham, Kellie A. Woodling, and Volodymyr Tryndyak.

Metrics

  • h-index: 31
  • Publications: 98
  • Citations: 2,753

Selected Publications

  • Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025) DOI
  • Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025) DOI
  • Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025) DOI
  • Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development (2025) DOI
  • A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024) DOI
  • The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024) DOI
  • Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022) DOI
  • Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats (2022) DOI
  • Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs (2022) DOI
  • Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats (2022) DOI
  • Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid (2021) DOI

Collaborators

Researchers in the database who share publications

Frederick A. Beland National Center for Toxicological Research 7 shared publications Michelle M. Vanlandingham National Center for Toxicological Research 3 shared publications Kellie A. Woodling National Center for Toxicological Research 3 shared publications Volodymyr Tryndyak National Center for Toxicological Research 2 shared publications Rose Willett National Center for Toxicological Research 2 shared publications Suresh K. Nagumalli National Center for Toxicological Research 2 shared publications Igor P. Pogribny National Center for Toxicological Research 2 shared publications Tucker A. Patterson National Center for Toxicological Research 2 shared publications

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