Angus M. MacNicol profile photo

Angus M. MacNicol

Federal Grant PI High Impact

Professor

University of Arkansas for Medical Sciences

faculty

Neurobiology & Developmental Science, College of Medicine

26 h-index 99 pubs 2,553 cited

Research Areas

Neuroscience and Neuropharmacology Research Cancer-related molecular mechanisms research RNA and protein synthesis mechanisms Diet and metabolism studies Cancer Treatment and Pharmacology Receptor Mechanisms and Signaling Molecular Biology Techniques and Applications

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Angus M. MacNicol's research investigates the molecular and cellular mechanisms underlying physiological processes, with a particular focus on neuroendocrinology and cancer biology. His work has explored the post-transcriptional regulation of gene expression in the anterior pituitary gland, examining how factors like the Musashi RNA-binding proteins influence the translation of key mRNAs involved in reproductive cycles and metabolic control. This includes studies on the role of leptin receptor signaling in somatotrope transcriptome maturation and the impact of high-fat diets on cell metabolism and oxidative stress within the pituitary.

In the realm of cancer research, MacNicol's laboratory has investigated the anti-cancer potential of specific compounds, including monensin and salinomycin analogs. These studies have utilized organoid and 3D cell culture models to assess the efficacy of these agents against glioblastoma and breast cancer stem-like cells, focusing on their ability to target and eliminate cancer stem cells.

MacNicol holds the designation of a high-impact researcher, evidenced by his h-index of 26 and over 2,500 citations across nearly 100 publications. He has served as a principal investigator on federal grants and collaborates extensively with researchers at the University of Arkansas for Medical Sciences, including Melanie Clair Macnicol, Gwen V. Childs, Angela K. Odle, and Anessa Haney, with whom he has co-authored numerous publications.

Metrics

  • h-index: 26
  • Publications: 99
  • Citations: 2,553

Selected Publications

  • OR13-08 Secretoneurin Modulates Gonadotrope Function Cyclically to Regulate LH Secretion (2025) DOI
  • SAT-001 Impact of VCD-induced Menopause on Gonadotrope Transcriptomics Reveals Estrogen-dependent Genes in the GnRH Signaling Pathway (2025) DOI
  • SAT-016 Musashi Contributes to the Specification and Maintenance of Distinct Pituitary Cell Lineages. (2025) DOI
  • Evaluation of the Activity of Monensin and Its Analogs for Modulation of Stem-like Cell Functionality in 2D and 3D Breast Cancer Models (2025) DOI
  • High fat diet-induced loss of pituitary plasticity in aging female mice with ablated leptin signaling in somatotropes (2025) DOI
  • Monensin and Its Analogs Exhibit Activity Against Breast Cancer Stem-Like Cells in an Organoid Model (2025) DOI
  • Ablation of Leptin Receptor Signaling Alters Somatotrope Transcriptome Maturation in Female Mice (2025) DOI
  • 8572 A 30% Maternal Caloric Restriction Alters Expression of Musashi Targets in the Neonatal and Adult Pituitary Proteomes of FVB Mice (2024) DOI
  • 8649 Ablation of Leptin Receptors in Somatotropes Impacts Transcriptomic Plasticity in the Pou1f1 Lineage of Female Pituitary Cells (2024) DOI
  • The Musashi RNA binding proteins direct the translational activation of key pituitary mRNAs (2024) DOI
  • Maternal undernutrition results in transcript changes in male offspring that may promote resistance to high fat diet induced weight gain (2024) DOI
  • Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023) DOI
  • FRI289 It Takes A Village: Musashi And Its Associated Proteins In The Adenohypophysis (2023) DOI
  • FRI290 Proteomic Identification Of Secretoneurin-Stimulated Proteins In Purified Mouse Gonadotropes (2023) DOI
  • OR20-03 Leptin-mediated Regulation Of Gene Regulatory Networks In Gonadotropes (2023) DOI

Grants & Funding

  • Maternal gene regulation in early vertebrate development NIH Principal Investigator
  • Control of pituitary cell plasticity through regulated mRNA translation NIH Principal Investigator
  • Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
  • G-quadruplex DNA as a chemical signaling agent NIH Co-Investigator
  • Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Arkansas Breast Cancer Research Program Principal Investigator
  • RAF-1 REGULATION DURING CELL GROWTH AND DIFFERENTIATION NIH Principal Investigator
  • Molecular mechanisms of pituitary plasticity NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
  • Small Molecule Chemical Screening for Inhibitors of Breast Cancer Tumor-Initiating Cell Self-Renewal Proliferation Arkansas Breast Cancer Research Program Principal Investigator

Collaborators

Researchers in the database who share publications

Melanie Clair Macnicol University of Arkansas for Medical Sciences 29 shared publications Gwen V. Childs University of Arkansas for Medical Sciences 27 shared publications Angela K. Odle University of Arkansas for Medical Sciences 21 shared publications Anessa Haney University of Arkansas for Medical Sciences 15 shared publications Tiffany K. Miles University of Arkansas for Medical Sciences 13 shared publications Alex Lagasse University of Arkansas for Medical Sciences 13 shared publications Jewel Banik University of Arkansas for Medical Sciences 11 shared publications Linda Hardy University of Arkansas for Medical Sciences 10 shared publications

Similar Researchers

Based on overlapping research topics

Gwen V. Childs University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research RNA and protein synthesis mechanisms Diet and metabolism studies
Good match 5 shared topics
Anessa Haney University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research RNA and protein synthesis mechanisms Diet and metabolism studies
Good match 5 shared topics
Katie R. Ryan University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Cancer Treatment and Pharmacology Receptor Mechanisms and Signaling
Good match 4 shared topics
Melanie Clair Macnicol University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research RNA and protein synthesis mechanisms Diet and metabolism studies
Good match 4 shared topics
Antiño R. Allen University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Diet and metabolism studies Cancer Treatment and Pharmacology
Good match 4 shared topics
Daniel Fil University of Arkansas for Medical Sciences
Neuroscience and Neuropharmacology Research Cancer-related molecular mechanisms research Diet and metabolism studies
Good match 4 shared topics