Amrita Khakurel

Researcher

University of Arkansas for Medical Sciences

faculty

6 h-index 16 pubs 156 cited

Research Areas

Cellular transport and secretion Glycosylation and Glycoproteins Research Protein Structure and Dynamics Molecular Biology Techniques and Applications Cancer-related molecular mechanisms research

Links

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OverviewAI-generated summary

Amrita Khakurel's research focuses on the cellular mechanisms governing protein trafficking and modification, particularly within the Golgi apparatus. Her work investigates the Golgi-associated retrograde protein (GARP) complex, a key component in vesicle tethering and transport. Publications detail the GARP complex's essential role in maintaining Golgi glycosylation machinery and its broader impact on cellular physiology. Research has explored how GARP dysfunction leads to defects in protein sorting, secretion, and O-glycosylation, affecting calcium homeostasis and COPI protein localization. Khakurel has also been involved in generating and analyzing specific cell lines, such as hTERT-RPE1 VPS54 knock-out lines, to further study these processes. Her scholarship metrics include an h-index of 6, with 156 total citations across 16 publications. Khakurel collaborates with researchers including Vladimir Lupashin, Tetyana Kudlyk, Irina D. Pokrovskaya, and Zinia D’Souza.

Metrics

  • h-index: 6
  • Publications: 16
  • Citations: 156

Selected Publications

  • Acute <scp>GARP</scp> Depletion Disrupts Vesicle Transport, Leading to Severe Defects in Sorting, Secretion and <i>O</i> ‐Glycosylation (2025) DOI
  • Acute GARP depletion disrupts vesicle transport, leading to severe defects in sorting, secretion, and O-glycosylation (2024) DOI
  • Role of GARP Vesicle Tethering Complex in Golgi Physiology (2023) DOI
  • GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins (2022) DOI
  • Generation and Analysis of hTERT-RPE1 VPS54 Knock-Out and Rescued Cell Lines (2022) DOI
  • GARP complex controls Golgi physiology by stabilizing COPI machinery and Golgi v-SNAREs (2022) DOI
  • Getting Sugar Coating Right! The Role of the Golgi Trafficking Machinery in Glycosylation (2021) DOI
  • The Golgi-associated retrograde protein (GARP) complex plays an essential role in the maintenance of the Golgi glycosylation machinery (2021) DOI

Collaborators

Researchers in the database who share publications

Vladimir Lupashin University of Arkansas for Medical Sciences 10 shared publications Tetyana Kudlyk National Center for Toxicological Research 4 shared publications Irina D. Pokrovskaya University of Arkansas for Medical Sciences 3 shared publications Zinia D’Souza University of Arkansas for Medical Sciences 3 shared publications I. V. Pokrovskaya University of Arkansas for Medical Sciences 3 shared publications Farhana Taher Sumya University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

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Cellular transport and secretion Protein Structure and Dynamics Molecular Biology Techniques and Applications
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Zinia D’Souza University of Arkansas for Medical Sciences
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Farhana Taher Sumya University of Arkansas for Medical Sciences
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Donald Catanzaro University of Arkansas for Medical Sciences
Cellular transport and secretion Protein Structure and Dynamics Molecular Biology Techniques and Applications
Good match 4 shared topics