Anupreet Kharbanda

Researcher

University of Arkansas for Medical Sciences

faculty

12 h-index 16 pubs 431 cited

Research Areas

Cancer Treatment and Pharmacology Computational Drug Discovery Methods Molecular Biology Techniques and Applications Protein Structure and Dynamics Cancer-related molecular mechanisms research Pharmacological Effects and Toxicity Studies Immune Response and Inflammation

Links

ORCID Lab Website

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OverviewAI-generated summary

Anupreet Kharbanda's research focuses on the discovery and development of novel therapeutic agents for cancer and other diseases. This work involves structure-based drug design and optimization, targeting specific molecular pathways implicated in disease progression. Publications include the identification of inhibitors for FLT3 and its mutants in acute myeloid leukemia, and N-trisubstituted pyrimidine derivatives as inhibitors of Type I RET and RET gatekeeper mutants.

Further research explores the potential of tocotrienols as an anti-breast cancer agent and the discovery of selective TGFβR1 inhibitors for immuno-oncology applications. Kharbanda also investigates novel non-kinase TGFβ pathway inhibitors and the destruction of DNA-binding proteins using programmable oligonucleotide PROTACs (O'PROTACs), targeting proteins like LEF1 and ERG. Collaborations include work with Yuet-Kin Leung, Brendan Frett, Phuc Tran, and Xiuqi Wang at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 12
  • Publications: 16
  • Citations: 431

Selected Publications

  • Revisiting Aurora Kinase B: A promising therapeutic target for cancer therapy (2023) DOI
  • Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose (2022) DOI
  • Tocotrienols as an Anti-Breast Cancer Agent (2021) DOI
  • Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (2021) DOI
  • Discovery of imidazo[1,2-a]pyridine-thiophene derivatives as FLT3 and FLT3 mutants inhibitors for acute myeloid leukemia through structure-based optimization of an NEK2 inhibitor (2021) DOI
  • Discovery of 4-aminoquinolines as highly selective TGFβR1 inhibitors with an attenuated MAP4K4 profile for potential applications in immuno-oncology (2021) DOI
  • Discovery and biological evaluation of phthalazines as novel non-kinase TGFβ pathway inhibitors (2021) DOI
  • Destruction of DNA-binding proteins by programmable O’PROTAC: Oligonucleotide-based PROTAC (2021) DOI

Collaborators

Researchers in the database who share publications

Yuet‐Kin Leung University of Arkansas for Medical Sciences 4 shared publications Brendan Frett University of Arkansas for Medical Sciences 4 shared publications Phuc Tran University of Arkansas for Medical Sciences 3 shared publications Xiuqi Wang University of Arkansas for Medical Sciences 2 shared publications Jaideep B. Bharate University of Arkansas for Medical Sciences 2 shared publications Jingwei Shao University of Arkansas for Medical Sciences 2 shared publications Christa Corley University of Arkansas for Medical Sciences 1 shared publication Pilar Simmons University of Arkansas for Medical Sciences 1 shared publication

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