Jingwei Shao

Researcher

University of Arkansas for Medical Sciences

faculty

8 h-index 11 pubs 321 cited

Research Areas

Protein Degradation and Inhibitors Molecular Biology Techniques and Applications Mitochondrial Function and Pathology Cancer-related molecular mechanisms research Drug Transport and Resistance Mechanisms

Links

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OverviewAI-generated summary

Jingwei Shao's research focuses on developing and applying novel molecular biology techniques for targeted protein degradation. Shao has investigated programmable oligonucleotide PROTACs (O'PROTACs) as a method to destroy DNA-binding proteins, specifically targeting LEF1 and ERG. This work includes exploring new cereblon ligands, such as 3-aminophthalic acid, to enhance O'PROTAC efficacy. Shao has also contributed to methods for the large-scale synthesis of PROTAC components, facilitating the rapid construction of PROTAC libraries. Another area of study involves the role of inositol in regulating mitochondrial fission through interaction with AMPK. Additionally, Shao's work has examined CD36-mediated endocytosis of proteolysis-targeting chimeras and high-throughput approaches to detect cytokine and chemokine secretion by human bone marrow endothelial cells.

Metrics

  • h-index: 8
  • Publications: 11
  • Citations: 321

Selected Publications

  • CD36-mediated endocytosis of proteolysis-targeting chimeras (2025) DOI
  • Feasible Column Chromatography-Free, Multi-Gram Scale Synthetic Process of VH032 Amine, Which Could Enable Rapid PROTAC Library Construction (2022) DOI
  • 3-Aminophthalic acid, a new cereblon ligand for targeted protein degradation by O’PROTAC (2022) DOI
  • Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK (2021) DOI
  • Destruction of DNA‐Binding Proteins by Programmable Oligonucleotide PROTAC (O'PROTAC): Effective Targeting of LEF1 and ERG (2021) DOI

Collaborators

Researchers in the database who share publications

Anupreet Kharbanda University of Arkansas for Medical Sciences 2 shared publications Phuc Tran University of Arkansas for Medical Sciences 2 shared publications Amit Ketkar University of Arkansas for Medical Sciences 1 shared publication Robert L. Eoff University of Arkansas for Medical Sciences 1 shared publication

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