Barbara L. Parsons Source Confirmed
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Research Microbiogist
National Center for Toxicological Research
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Biography and Research Information
OverviewAI-generated summary
Barbara L. Parsons, a Research Microbiologist at the National Center for Toxicological Research, has a research program focused on the application of next-generation sequencing (NGS) technologies for genotoxicity and cancer risk assessment. Her work investigates the use of error-corrected NGS to improve the accuracy and sensitivity of detecting small genetic variants, particularly those with low allele frequencies, which are critical for understanding cancer development and assessing potential carcinogens.
Parsons has published on the performance of cancer gene panels and the interpretation of in vitro concentration-response data for regulatory decision-making. Her research includes studies on the measurement of cancer driver mutations in various tissues and their correlation with spontaneous tumor incidence in animal models. She has also investigated the detection of specific mutation expansions induced by chemical agents, such as lorcaserin, in rat mammary tissue.
Her scholarship metrics include an h-index of 29, with 146 total publications and 2,817 total citations. Parsons is recognized as a highly cited researcher. She actively collaborates with colleagues at the National Center for Toxicological Research, including Meagan B. Myers, Robert H. Heflich, Binsheng Gong, and Kelly L. Harris, with whom she has co-authored multiple publications.
Metrics
- h-index: 29
- Publications: 146
- Citations: 2,817
Selected Publications
- Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in <scp>rasH2</scp> ‐Tg Mice (2025) DOI
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing (2025) DOI
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
- CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024) DOI
- <scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>) (2024) DOI
- Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 <scp>IWGT</scp> quantitative analysis expert working group meeting (2023) DOI
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment (2023) DOI
- Interpretation of In Vitro Concentration-Response Data for Risk Assessment and Regulatory Decision-making: Report from 2022 IWGT Quantitative Analysis Expert Working Group Meeting (2023) DOI
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing (2023) DOI
- Launching the “Projections” series in mutation research reviews with a special issue on next generation sequencing (2021) DOI
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia (2021) DOI
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency (2021) DOI
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions (2021) DOI
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