Binsheng Gong Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Visiting Scientist

National Center for Toxicological Research

faculty

17 h-index 91 pubs 2,922 cited

Research Areas

Cancer Genomics and Diagnostics Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks Genomics and Phylogenetic Studies Analytical Chemistry and Chromatography Carcinogens and Genotoxicity Assessment

Links

ORCID Research Group

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OverviewAI-generated summary

Binsheng Gong's research focuses on the analytical validity and performance assessment of genomic sequencing assays, particularly for cancer diagnostics. Gong has published work evaluating circulating tumor DNA sequencing for precision oncology, and the development of reference samples for assessing cancer panels that detect small variants of low allele frequency. Studies have also investigated the sensitivity, accuracy, and genomic region-dependent performance of oncopanels, as well as quality degradation in FFPE-processed samples. Further research includes ultra-deep sequencing data from liquid biopsy proficiency studies and the measurement of cancer driver mutations in rat models. Gong has collaborated with researchers from the University of Arkansas for Medical Sciences and the National Center for Toxicological Research, including Donald J. Johann, Joshua Xu, Barbara L. Parsons, and Dan Li.

Metrics

  • h-index: 17
  • Publications: 91
  • Citations: 2,922

Selected Publications

  • 2025 White Paper on Recent Issues in Bioanalysis: Redosing Patients with AAV Gene Therapy; CRS Immunogenicity Risk; Shedding Assays; NHP Studies Immunogenicity; CMC vs Bioanalytical Assays; Artificial Intelligence-Powered Genomic Pipelines for NGS ( <u>PART 3A</u> – Recommendations on Gene, Cell, and Vaccine Therapies Immunogenicity &amp; Technologies; Biotherapeutics &amp; Biosimilars Immunogenicity Assessment &amp; Clinical Relevance <u>PART 3B</u> – Regulatory Agencies’ Input on Immunogenicity/Technologies of Biotherapeutics, Gene, Cell &amp; Vaccine Therapies) (2025) DOI
  • Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in <scp>rasH2</scp> ‐Tg Mice (2025) DOI
  • Dissecting Sex‐Specific Pathology in K18‐hACE2 Transgenic Mice Infected With Different SARS‐CoV‐2 Variants (2025) DOI
  • Augmenting precision medicine via targeted RNA-Seq detection of expressed mutations (2025) DOI
  • Zika and dengue viruses differentially modulate host mRNA processing factors defining its virulence (2025) DOI
  • Targeted DNA-seq and RNA-seq of Reference Samples with Short-read and Long-read Sequencing (2024) DOI
  • Towards accurate indel calling for oncopanel sequencing through an international pipeline competition at precisionFDA (2024) DOI
  • Extend the benchmarking indel set by manual review using the individual cell line sequencing data from the Sequencing Quality Control 2 (SEQC2) project (2024) DOI
  • Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application (2023) DOI
  • Deep oncopanel sequencing reveals within block position-dependent quality degradation in FFPE processed samples (2022) DOI
  • Ultra-deep multi-oncopanel sequencing of benchmarking samples with a wide range of variant allele frequencies (2022) DOI
  • Ultra-deep sequencing data from a liquid biopsy proficiency study demonstrating analytic validity (2022) DOI
  • Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity (2021) DOI
  • Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia (2021) DOI
  • Evaluating the analytical validity of circulating tumor DNA sequencing assays for precision oncology (2021) DOI

Collaborators

Researchers in the database who share publications

Donald J. Johann University of Arkansas for Medical Sciences 11 shared publications Joshua Xu National Center for Toxicological Research 11 shared publications Barbara L. Parsons National Center for Toxicological Research 6 shared publications Dan Li National Center for Toxicological Research 6 shared publications Mary Qu Yang University of Arkansas at Little Rock 6 shared publications Weida Tong National Center for Toxicological Research 4 shared publications Kelly L. Harris National Center for Toxicological Research 4 shared publications Leihong Wu National Center for Toxicological Research 3 shared publications

Similar Researchers

Based on overlapping research topics

Penelope Duerken-Hughes National Center for Toxicological Research
Cancer Genomics and Diagnostics Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks
Strong match 4 shared topics
Dan Li National Center for Toxicological Research
Cancer Genomics and Diagnostics Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks
Strong match 5 shared topics
Joe Meehan National Center for Toxicological Research
Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks Genomics and Phylogenetic Studies
Good match 4 shared topics
Barbara L. Parsons National Center for Toxicological Research
Cancer Genomics and Diagnostics Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks
Good match 4 shared topics
Karen L. McKim National Center for Toxicological Research
Cancer Genomics and Diagnostics Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 4 shared topics
Meagan B. Myers National Center for Toxicological Research
Cancer Genomics and Diagnostics Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks
Good match 4 shared topics