Daniel E. Voth

Federal Grant PI High Impact

Department Chairperson

University of Arkansas for Medical Sciences

faculty

Department Chairs, College of Medicine

30 h-index 75 pubs 21,566 cited

Research Areas

Microbial infections and disease research Immune Response and Inflammation Bacterial Genetics and Biotechnology Host-Pathogen Interactions Molecular Biology Techniques and Applications Health Sciences Research and Education Genomics and Phylogenetic Studies Metabolism and Genetic Disorders

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Daniel E. Voth's research investigates host-pathogen interactions, focusing on the mechanisms by which microbes invade the human lung and evade host defenses. His work has explored the role of neurotransmitter systems in targeting the growth of *Coxiella burnetii*, the agent responsible for Q fever, and how microRNAs contribute to the host's response to this bacterium. Voth has also examined metabolic regulation in lung macrophages concerning host defense against bacterial infections and has contributed to the development of models for studying pathogen invasion, including ex vivo lung tissue models.

His laboratory has also been involved in the genetic manipulation of spirochetes, specifically *Borrelia duttonii*, a causative agent of tick-borne relapsing fever. Voth has secured significant federal funding, totaling over $8.4 million, from agencies such as the National Institutes of Health (NIH). These grants support his studies on how *Coxiella burnetii* subverts host antioxidant signaling, the impact of host-directed drugs on bacterial growth in macrophages, and the expansion of research capacity for animal models of infection through the establishment of a Center for Animal Models of Infection and Disease (CAMID).

With a career h-index of 30 and over 21,000 citations across 75 publications, Voth is recognized as a highly cited researcher. He maintains collaborations with colleagues at the University of Arkansas for Medical Sciences and actively manages a lab website to disseminate research findings. He also holds the position of Department Chairperson within the College of Medicine at the University of Arkansas for Medical Sciences.

Metrics

h-index: 30
Publications: 75
Citations: 21,566

Selected Publications

Coxiella burnetii Nine Mile II Δ cbu0533 as a suitable laboratory replacement strain (2025) DOI
β-glucan-induced monocyte-derived alveolar macrophages confer protection against Mycobacterium tuberculosis 4395 (2025) DOI
Control of human Q fever by vaccination: the journey to Q-VAX and beyond (2025) DOI
Coxiella burnetii Strains Elicit Distinct Inflammatory Responses in Human Macrophages (2025) DOI
The intracellular agent of Q fever, Coxiella burnetii , alters human alveolar macrophage metabolism and mitochondrial physiology (2025) DOI
Coxiella burnetii strains elicit distinct inflammatory responses in human macrophages (2025) DOI
Guanylate-Binding Proteins Promote Host Defense Against Leishmania major by Balancing iNOS/Arg-1 in Myeloid Cells (2025) DOI
Embracing multiple infection models to tackle Q fever: A review of in vitro, in vivo, and lung ex vivo models (2024) DOI
Development and validation of systems for genetic manipulation of the Old World tick-borne relapsing fever spirochete, Borrelia duttonii (2024) DOI
MicroRNAs Contribute to Host Response to Coxiella burnetii (2022) DOI
Editorial: Obligate intracellular bacteria: Evasion and adaptative tactics shaping the host-pathogen interface (2022) DOI
Breathe In, Breathe Out: Metabolic Regulation of Lung Macrophages in Host Defense Against Bacterial Infection (2022) DOI
MicroRNAs contribute to the host response to Coxiella burnetii (2022) DOI
Neurotransmitter System-Targeting Drugs Antagonize Growth of the Q Fever Agent, Coxiella burnetii, in Human Cells (2021) DOI
Take my breath away: studying pathogen invasion of the human lung using primary tissue models (2021) DOI

Federal Grants 4 $8,412,384 total

NIH/National Institute of Allergy and Infectious Diseases Contact PI Jun 2024 - Apr 2026

Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages

National Institute of Allergy and Infectious Diseases $191,250 R21

NIH/NIH Office of the Director Contact PI Sep 2022 - May 2027

Expanding UAMS Research Capacity to Establish a Center for Animal Models of Infection and Disease (CAMID)

NIH Office of the Director $7,975,000 C06

NIH/National Institute of Allergy and Infectious Diseases Contact PI Sep 2020 - Aug 2023

Coxiella burnetii Subversion of Host Nrf2 Antioxidant Signaling- Resubmission

National Institute of Allergy and Infectious Diseases $186,034 R21

NIH/National Institute of General Medical Sciences Contact PI Mar 2000 - Dec 2022

Glycan Expression Analysis using an Odyssey CLx Infrared Imaging System

National Institute of General Medical Sciences $60,100 R01

Grants & Funding

Coxiella burnetii Regulation of Macrophage cAMP/PKA Signaling NIH Principal Investigator
Defining the impact of host-directed drugs on Coxiella burnetii growth in macrophages UAMS Internal Research Awards Principal Investigator
Bacterial cell wall synthesis, shape and septation NIH Principal Investigator
Role of the Coxiella burnetii Cryptic Plasmid in Host Cell Parasitism NIH Principal Investigator
Manipulation of host signaling by the Q fever agent, Coxiella burnetii American Heart Association (South Central Affiliate) Principal Investigator
Coxiella burnetii Subversion of Host Nrf2 Antioxidant Signaling- Resubmission NIH Principal Investigator
A Novel Human Lung Infection Platform to Define Staphylococcus aureus Virulence Determinants NIH Principal Investigator
Defining Coxiella burnetii Infection of Primary Human Cardiac Cells NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator