Hui‐Ming Chang

Federal Grant PI High Impact

Professor

University of Arkansas for Medical Sciences

faculty

23 h-index 66 pubs 2,821 cited

Research Areas

Neuroscience and Neuropharmacology Research Blood Pressure and Hypertension Studies Molecular Biology Techniques and Applications Immune Response and Inflammation Acute Myeloid Leukemia Research Pharmacological Effects and Toxicity Studies Cancer-related molecular mechanisms research Protein Degradation and Inhibitors

Links

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OverviewAI-generated summary

Hui-Ming Chang's research focuses on understanding the molecular and cellular mechanisms underlying various physiological and pathological processes. A significant portion of this work investigates the role of ion channels, specifically Kv7 channels, in hypertension and sympathetic outflow, examining their activity within the central amygdala. Chang also studies the involvement of corticotropin-releasing hormone neurons in stress-induced hypertension and the signaling pathways that regulate their function, including NMDA receptor activity and M-channels.

Further research explores the regulation of Toll-like receptor 4 (TLR4) signaling through the TRAF6/sNASP axis, focusing on reversible phosphorylation mediated by CK2 and PP4. Chang's work extends to hematological malignancies, investigating how dipeptidylpeptidase 4 influences the survival and stemness of acute myeloid leukemia stem cells. Additionally, Chang has contributed to understanding anthracycline-induced cardiotoxicity, examining the mechanisms and prevention strategies, including the role of dexrazoxane in degrading topoisomerase 2b.

Chang is a highly cited researcher with a substantial publication record and has served as a principal investigator on federal grants. Chang leads a research group at the University of Arkansas for Medical Sciences and collaborates with other researchers at the institution, including Edward T.H. Yeh and J.C. Hsu.

Metrics

h-index: 23
Publications: 66
Citations: 2,821

Selected Publications

Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment (2025) DOI
Abstract 12348: Targeted Degradation of Topoisomerase 2b by Dexrazoxane for Prevention of Doxorubicin-Induced Cardiotoxicity: Dose and Time Course Study in Human (2023) DOI
Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension (2023) DOI
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells (2023) DOI
Signaling pathways involved in <scp>NMDA</scp>‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala (2022) DOI
Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4 (2022) DOI
Abstract 9710: Prevention of Doxorubicin-Induced Cardiotoxicity Through Targeted Degradation of Topoisomerase 2b (2021) DOI
Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4 (2021) DOI
Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension (2021) DOI