Jaime A. Miranda Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Biologist

National Center for Toxicological Research

faculty

6 h-index 12 pubs 99 cited

Research Areas

Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Microbial infections and disease research Pharmacological Effects and Toxicity Studies Bioinformatics and Genomic Networks Antibiotic Resistance in Bacteria

Links

ORCID

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OverviewAI-generated summary

Jaime A. Miranda's research focuses on evaluating the mutagenic effects of various chemical exposures using advanced sequencing technologies. His work has involved assessing the mutagenicity of compounds like Molnupiravir and N-nitrosodimethylamine in both bacterial and mammalian cell cultures, including 2D and 3D HepaRG cell models. Miranda utilizes PacBio and HiFi sequencing methods to detect genome-wide, ultra-low-frequency substitution mutations resulting from these exposures. He has also investigated the application of long-read sequencing for in vivo chemical mutagenesis assessment and for detecting off-target mutations in genome-edited cell populations. His research extends to analyzing whole-genome sequences of multidrug-resistant bacteria, such as E. coli and Citrobacter freundii, to understand antibiotic resistance and plasmid dynamics. Miranda has a notable publication record in this field, with 12 total publications and 99 citations, and maintains collaborations with several researchers at the National Center for Toxicological Research.

Metrics

  • h-index: 6
  • Publications: 12
  • Citations: 99

Selected Publications

  • Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025) DOI
  • Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025) DOI
  • Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection (2024) DOI
  • Assessment of in vivo chemical mutagenesis by long-read sequencing (2024) DOI
  • Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
  • Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp (2024) DOI
  • Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024) DOI
  • Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023) DOI
  • Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp (2023) DOI
  • Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022) DOI
  • Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022) DOI
  • <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens (2021) DOI

Collaborators

Researchers in the database who share publications

Javier R. Revollo National Center for Toxicological Research 11 shared publications Page B. McKinzie National Center for Toxicological Research 4 shared publications Vasily N. Dobrovolsky National Center for Toxicological Research 4 shared publications Robert H. Heflich National Center for Toxicological Research 3 shared publications Saeed Khan National Center for Toxicological Research 3 shared publications Kidon Sung National Center for Toxicological Research 3 shared publications Nan Mei National Center for Toxicological Research 2 shared publications Yuan Le National Center for Toxicological Research 2 shared publications

Similar Researchers

Based on overlapping research topics

Page B. McKinzie National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Strong match 6 shared topics
Javier R. Revollo National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Strong match 6 shared topics
Azra Dad National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Strong match 5 shared topics
Vasily N. Dobrovolsky National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 5 shared topics
Douglas D. Rhoads University of Arkansas at Fayetteville
Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Microbial infections and disease research
Good match 6 shared topics
Joe Meehan National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 4 shared topics