Vasily N. Dobrovolsky Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

28 h-index 105 pubs 2,530 cited

Research Areas

Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Bioinformatics and Genomic Networks Pharmacological Effects and Toxicity Studies CRISPR and Genetic Engineering Neuroscience and Neuropharmacology Research

Links

ORCID Lab Website

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OverviewAI-generated summary

Vasily N. Dobrovolsky's research focuses on the detection and characterization of mutations, particularly in the context of chemical exposure and genetic engineering. He has investigated the utility of high-fidelity (HiFi) and PacBio sequencing technologies for identifying genome-wide, ultra-low-frequency substitution mutations. His work has explored these methods for assessing the mutagenic effects of specific chemical compounds, such as Molnupiravir and N4-hydroxycytidine, in both bacterial and mammalian cell systems, as well as in vivo studies.

Further research by Dobrovolsky has involved the application of whole-genome sequencing to detect off-target mutations in genome-edited cell populations. He has also contributed to neurotoxicity testing by establishing neural stem cell lines from fetal monkey brains. His scholarship metrics include an h-index of 28, with 105 total publications and 2,530 total citations, designating him as a highly cited researcher. Dobrovolsky collaborates with researchers at the National Center for Toxicological Research, including Page B. McKinzie, Javier R. Revollo, Jaime A. Miranda, and Robert H. Heflich, with whom he shares multiple publications.

Metrics

  • h-index: 28
  • Publications: 105
  • Citations: 2,530

Selected Publications

  • Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026) DOI
  • Application of error-corrected sequencing technologies for in vivo regulatory mutagenicity assessment (2025) DOI
  • Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin (2024) DOI
  • Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023) DOI
  • Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023) DOI
  • Establishment of neural stem cells from fetal monkey brain for neurotoxicity testing (2023) DOI
  • Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022) DOI
  • Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022) DOI
  • <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens (2021) DOI
  • Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine (2021) DOI
  • <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021) DOI

Collaborators

Researchers in the database who share publications

Page B. McKinzie National Center for Toxicological Research 9 shared publications Javier R. Revollo National Center for Toxicological Research 8 shared publications Jaime A. Miranda National Center for Toxicological Research 4 shared publications Robert H. Heflich National Center for Toxicological Research 3 shared publications Mason G. Pearce National Center for Toxicological Research 3 shared publications Azra Dad National Center for Toxicological Research 1 shared publication Alexander W. Alund National Center for Toxicological Research 1 shared publication Mackean P. Maisha National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Javier R. Revollo National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Strong match 6 shared topics
Azra Dad National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Strong match 5 shared topics
Jaime A. Miranda National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 5 shared topics
Joe Meehan National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 4 shared topics
Page B. McKinzie National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 5 shared topics
Dan Li National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies
Good match 5 shared topics