Xiaobo He Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

faculty

15 h-index 49 pubs 541 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Metabolism and Genetic Disorders Diet and metabolism studies Drug Transport and Resistance Mechanisms Molecular Biology Techniques and Applications Plant Physiology and Cultivation Studies

Links

ORCID Lab Website Research Group

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OverviewAI-generated summary

Xiaobo He's research focuses on the evaluation of genotoxicity and cytotoxicity of various compounds, employing human cell lines and primary hepatocytes. His work has investigated the role of cytochrome P450 enzymes in the metabolic activation and detoxification of substances, including naturally occurring compounds like luteolin and pyrrolizidine alkaloids, as well as pharmaceutical agents such as lapatinib. He has also explored the pharmacokinetics of nicotine and its metabolites in animal models, utilizing different administration routes to understand systemic exposure. Further research includes the development and application of a human placental barrier model for studying drug transfer and the genotoxicity assessment of nitrosamine impurities. He has collaborated with researchers at the National Center for Toxicological Research, including Matthew Bryant, Nan Mei, Ji‐Eun Seo, and Xilin Li, contributing to a body of work in toxicology and drug metabolism.

Metrics

h-index: 15
Publications: 49
Citations: 541

Selected Publications

Mechanistic study of pexidartinib-induced toxicity in human hepatic cells (2025) DOI
Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025) DOI
Comparative DNA damage induced by eight nitrosamines in primary human and macaque hepatocytes (2025) DOI
An efficient enzymatic system for studying structure-carcinogenicity relationships: metabolism of pyrrolizidine alkaloids by human liver microsomes in the presence of calf thymus DNA, resulting in the formation of DNA adducts (2024) DOI
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024) DOI
Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024) DOI
Evaluation of a microphysiological human placental barrier model for studying placental drug transfer (2023) DOI
The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023) DOI
Formation of DHP-DNA Adducts from Rat Liver Microsomal Metabolism of 1,2-Unsaturated Pyrrolizidine Alkaloid-Containing Plant Extracts and Dietary Supplements (2023) DOI
Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022) DOI
Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021) DOI
Genotoxicity evaluation using primary hepatocytes isolated from rhesus macaque (Macaca mulatta) (2021) DOI
The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells (2021) DOI