Roberta A. Mittelstaedt Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

24 h-index 64 pubs 1,722 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Cancer-related molecular mechanisms research DNA Repair Mechanisms Toxicology

Links

ORCID

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Roberta A. Mittelstaedt's research focuses on investigating the genotoxicity and mutagenicity of various chemical agents, particularly in the context of toxicological studies. Her work employs a range of in vitro and in vivo models, including human organotypic airway cultures and rodent systems, to assess DNA damage and mutation induction. Recent publications explore the genetic toxicity testing of specific compounds like N-nitrosamines and NNK, utilizing methods such as the CometChip assay, Duplex Sequencing, and the Ames test. She has also investigated dose-response assessments for genotoxicity induced by ethyl methane sulfonate and whole cigarette smoke solutions, considering factors like life stage and target tissue.

Mittelstaedt has a publication record of 64 papers, with 1,722 citations, and an h-index of 24. She has collaborated with researchers primarily from the National Center for Toxicological Research, including Robert H. Heflich, Nan Mei, Xuefei Cao, and Joseph G. Shaddock. Her recent activity is confirmed by publications extending into 2025, indicating ongoing research in her field.

Metrics

  • h-index: 24
  • Publications: 64
  • Citations: 1,722

Selected Publications

  • Detection of In Vivo Mutation in the Hprt and Pig-a Genes of Rat Lymphocytes (2025) DOI
  • Optimizing the detection of N-nitrosamine mutagenicity in the Ames test (2024) DOI
  • Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
  • Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023) DOI
  • Effect of life stage and target tissue on dose–response assessment of ethyl methane sulfonate‐induced genotoxicity (2021) DOI
  • Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing (2021) DOI
  • Toxicokinetic and Genotoxicity Study of NNK in Male Sprague Dawley Rats Following Nose-Only Inhalation Exposure, Intraperitoneal Injection, and Oral Gavage (2021) DOI
  • Differentiating between micronucleus dose-responses induced by whole cigarette smoke solutions with Benchmark Dose potency ranking (2021) DOI

Collaborators

Researchers in the database who share publications

Robert H. Heflich National Center for Toxicological Research 7 shared publications Nan Mei National Center for Toxicological Research 4 shared publications Xuefei Cao National Center for Toxicological Research 3 shared publications Joseph G. Shaddock National Center for Toxicological Research 2 shared publications Yuan Le National Center for Toxicological Research 2 shared publications Rebecca Wynne National Center for Toxicological Research 2 shared publications Michelle E. Bishop National Center for Toxicological Research 2 shared publications Mason G. Pearce National Center for Toxicological Research 2 shared publications

Similar Researchers

Based on overlapping research topics

Jade N. Hess National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Strong match 4 shared topics
C. J. Branscomb National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Cancer-related molecular mechanisms research
Strong match 4 shared topics
Mason G. Pearce National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Strong match 4 shared topics
Ji‐Eun Seo National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Good match 4 shared topics
Sharon D. Shelton National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Good match 3 shared topics
W. SLIKKKER National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications
Good match 3 shared topics