Thomas A. Williams

High Impact

Senior Assistant Professor

University of Arkansas for Medical Sciences

faculty

21 h-index 143 pubs 3,109 cited

Research Areas

CAR-T cell therapy research Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology Molecular Biology Techniques and Applications Health and Medical Research Impacts Cancer-related molecular mechanisms research Epigenetics and DNA Methylation

Links

ORCID Lab Website

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OverviewAI-generated summary

Thomas A. Williams' research centers on the biological mechanisms underlying immune cell function, particularly focusing on T cells. His recent work investigates strategies to enhance CAR-T cell persistence and effector function. This includes studying the role of EZH2 inhibition in improving CD8+ CAR-T cell persistence and the impact of CD28 costimulation on T cell metabolism through PCK2. Williams also explores manipulating the DNA damage response to counteract T cell exhaustion and improve immunotherapy outcomes.

Williams has a significant publication record, with 143 total publications and over 3,100 citations, contributing to an h-index of 21. He is recognized as a highly cited researcher. His collaborations include work with Brian Koss, Katherine Wallis, Daniel Fil, and Lora J. Rogers, all from the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications. Williams maintains an active laboratory website to share his research.

Metrics

  • h-index: 21
  • Publications: 143
  • Citations: 3,109

Selected Publications

  • 685 EZH2 inhibition impairs CD8+ CAR-T cell persistence (2025) DOI
  • 762 CD28 costimulation induces PCK2 to support T cell effector function in metabolically hostile environments (2025) DOI
  • 236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025) DOI

Collaborators

Researchers in the database who share publications

Brian Koss University of Arkansas for Medical Sciences 3 shared publications Katherine Wallis University of Arkansas for Medical Sciences 3 shared publications Daniel Fil University of Arkansas for Medical Sciences 3 shared publications Lora J. Rogers University of Arkansas for Medical Sciences 3 shared publications Mousumi Patra University of Arkansas for Medical Sciences 1 shared publication Jacob L Edmondson University of Arkansas for Medical Sciences 1 shared publication Megan R. Reed University of Arkansas for Medical Sciences 1 shared publication Billie Heflin University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Yong‐Chen Lu University of Arkansas for Medical Sciences
Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology
Good match 5 shared topics
Mayumi Nakagawa University of Arkansas for Medical Sciences
Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology
Good match 5 shared topics
Jacob L Edmondson University of Arkansas for Medical Sciences
Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology
Good match 5 shared topics
John D. Shaughnessy Jr. University of Arkansas for Medical Sciences
Immune Cell Function and Interaction Cancer Immunotherapy and Biomarkers T-cell and B-cell Immunology
Good match 5 shared topics
Jessica L. Kelliher University of Arkansas for Medical Sciences
CAR-T cell therapy research Immune Cell Function and Interaction Health and Medical Research Impacts
Good match 4 shared topics
Latambria Hampton University of Arkansas for Medical Sciences
Immune Cell Function and Interaction T-cell and B-cell Immunology Molecular Biology Techniques and Applications
Good match 4 shared topics