Edward T.H. Yeh
Chairman
University of Arkansas for Medical Sciences
faculty
Department Chairs, College of Medicine
Research Areas
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Biography and Research Information
OverviewAI-generated summary
Edward T.H. Yeh leads a research group focused on cellular and molecular mechanisms underlying physiological processes and disease states. His work investigates the regulation of ion channels, specifically Kv7 channels, and their role in hypertension and sympathetic outflow. Yeh's research also explores the function of SUMO-specific proteases, such as SENP2, in cellular processes like adrenal cortex differentiation and neurogenesis, and their impact on conditions like isolated glucocorticoid deficiency. Additionally, his group studies signaling pathways involving Toll-like receptor 4 (TLR4) and its regulators in immune responses, as demonstrated by research on acute lung injury. More recently, Yeh's publications have examined the role of dipeptidylpeptidase 4 in acute myeloid leukemia stem cells, contributing to an understanding of cancer stem cell survival and stemness.
Metrics
- h-index: 86
- Publications: 275
- Citations: 28,635
Selected Publications
- CYLD links the TRAF6/sNASP axis to TLR4 signaling in sepsis-induced acute lung injury (2025) DOI
- Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment (2025) DOI
- Abstract 12348: Targeted Degradation of Topoisomerase 2b by Dexrazoxane for Prevention of Doxorubicin-Induced Cardiotoxicity: Dose and Time Course Study in Human (2023) DOI
- Lactate: an intracellular metabolite regulates cell cycle progression (2023) DOI
- Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension (2023) DOI
- Promises and challenges of machine learning for device therapy in heart failure (2023) DOI
- Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells (2023) DOI
- Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation in mice (2022) DOI
- Signaling pathways involved in <scp>NMDA</scp>‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala (2022) DOI
- Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4 (2022) DOI
- PEP-sNASP Peptide Alleviates LPS-Induced Acute Lung Injury Through the TLR4/TRAF6 Axis (2022) DOI
- Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation (2022) DOI
- Abstract 9710: Prevention of Doxorubicin-Induced Cardiotoxicity Through Targeted Degradation of Topoisomerase 2b (2021) DOI
- Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4 (2021) DOI
- L’excès de SUMOylation altère l’homéostasie postnatale du cortex surrénalien et conduit à un déficit isolé en glucocorticoïde (2021) DOI
Grants & Funding
- Doxorubicin-induced Cardiotoxicity: The Role of Topoisomerase 2b NIH/Nat. Heart, Lung & Blood Institute Principal Investigator
- PATHOBIOCHEMISTRY OF ACUTE PROMYELOCYTIC LEUKEMIA NIH Principal Investigator
- Doxorubicin-induced Cardiotoxicity: The Role of Topoisomerase 2b NIH/Nat. Heart, Lung & Blood Institute Principal Investigator
- Prevention of Heart Failure induced by Doxorubicin with Early Administration of Dexrazoxane NIH/Nat. Heart, Lung & Blood Institute Co-Investigator
- Doxorubicin-induced Cardiotoxicity: the Role of Topoisomerase 2b NIH Principal Investigator
- De-SUMOylation and the Hypoxic Response NIH Principal Investigator
- STUDIES OF THE SENTRIN FAMILY OF UBIQUITIN-LIKE PROTEINS NIH Principal Investigator
- PATHOBIOLOGY OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA NIH Principal Investigator
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