Merle G. Paule Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

52 h-index 336 pubs 10,678 cited

Research Areas

Neuroscience and Neuropharmacology Research Behavioral and Psychological Studies Pharmacological Effects and Toxicity Studies Birth, Development, and Health Child and Adolescent Health Maternal and Perinatal Health Interventions Medical Imaging Techniques and Applications Carcinogens and Genotoxicity Assessment

Links

ORCID

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OverviewAI-generated summary

Merle G. Paule's research focuses on the neurodevelopmental and behavioral effects of prenatal and early-life exposures, particularly trace elements and environmental contaminants. Investigations have examined the association between prenatal metal mixtures and learning deficits, reward motivation, and sexually dimorphic impacts of lead exposure on behavioral performance in children. Additionally, Paule has studied the neurochemical effects of general anesthesia in infant rhesus monkeys and the consequences of methylphenidate treatment and withdrawal in nonhuman primates, utilizing MicroPET/CT and MRI imaging techniques.

Paule's work also includes quantitative analysis of neurotoxicity in rat models, such as the effects of trimethyltin exposure on the brain. Collaborations with researchers at the National Center for Toxicological Research, including John J. Chelonis, Serguei Liachenko, John Talpos, and William Slikker, have resulted in shared publications exploring these toxicological and neurobehavioral themes. With a highly cited designation, Paule has authored 336 publications, accumulating over 10,678 citations and an h-index of 52, indicating significant contributions to the field.

Metrics

h-index: 52
Publications: 336
Citations: 10,678

Selected Publications

Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024) DOI
Performance of the prospective T2 MRI biomarker of neurotoxicity in a trimethyltin model in rats at 7 T (2023) DOI
Discontinuation of methylphenidate after long-term exposure in nonhuman primates (2023) DOI
The effects of long-term methylphenidate administration and withdrawal on progressive ratio responding and T2 MRI in the male rhesus monkey (2022) DOI
Prenatal trace elements mixture is associated with learning deficits on a behavioral acquisition task among young children (2022) DOI
Sexually dimorphic associations between prenatal blood lead exposure and performance on a behavioral testing battery in children (2022) DOI
Prenatal metal mixture concentrations and reward motivation in children (2021) DOI
Sexually dimorphic associations between prenatal blood lead exposure and temporal processing in 6- to 7-year-old children in Mexico City (2021) DOI
MicroPET/CT assessment of neurochemical effects in the brain after long-term methylphenidate treatment in nonhuman primates (2021) DOI
Global Neurotoxicity: Quantitative Analysis of Rat Brain Toxicity Following Exposure to Trimethyltin (2021) DOI
General anaesthesia during infancy reduces white matter micro-organisation in developing rhesus monkeys (2021) DOI