Isabelle Racine Miousse

Federal Grant PI High Impact

Assistant Professor

University of Arkansas for Medical Sciences

faculty

Biochemistry & Molecular Biology, College of Medicine

iracinemiousse@uams.edu

29 h-index 88 pubs 2,930 cited

Research Areas

Diet and metabolism studies Cancer Treatment and Pharmacology Radiation Therapy and Dosimetry Phytochemicals and Antioxidant Activities Immune Response and Inflammation Metabolism and Genetic Disorders Molecular Biology Techniques and Applications Cancer-related molecular mechanisms research

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Isabelle Racine Miousse, an Assistant Professor in Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences, investigates the metabolic and molecular underpinnings of radiation injury and cancer. Her research group focuses on understanding how dietary interventions, specifically methionine restriction, can influence the body's response to radiation and enhance the efficacy of cancer treatments, such as immune checkpoint inhibitors.

Dr. Miousse's work has explored the role of gamma-tocotrienol, a compound derived from palm oil, as a radioprotective agent. Studies have examined its effects on mitigating intestinal and hematopoietic injury following total-body and partial-body irradiation in nonhuman primate models. Additionally, her lab investigates the cellular mechanisms of cell death in response to nutrient depletion, characterizing methionine dependence in melanoma cells and examining the impact of dietary methionine deficiency on genetic instability in immune cells.

With an h-index of 29 and over 2,930 citations across 88 publications, Dr. Miousse is recognized as a highly cited researcher. She has secured federal funding, including a $153,000 grant from the NIH to study methionine metabolism in the gut's acute response to radiation. Her research network includes active collaborations with colleagues at the University of Arkansas for Medical Sciences, such as Sarita Garg, Lauren C. Morehead, Alan J. Tackett, and Katherine Wallis.

Metrics

h-index: 29
Publications: 88
Citations: 2,930

Selected Publications

Multimodal reprogramming of the tumor microenvironment by MMR and dual checkpoint blockade in hepatocellular carcinoma models (2025) DOI
Exposure to a Single Dose of Space-Relevant Proton Radiation Alters the Intestinal One-Carbon Metabolism Pathway and Microbiome in Mice (2025) DOI
Pancreatic tumor microenvironment reprogramming via alloantigen-expressing virotherapy elicits tumor rejection and improves immunotherapy response (2025) DOI
Enhancing Rectal Cancer Radiosensitivity and Gut Protection through Methionine Restriction (2025) DOI
GLP-1 receptor agonists in the context of cancer: the road ahead (2025) DOI
Abstract 950: Engineered oncolytic vesiculovirus downsizes pancreatic tumor and boosts immune response (2025) DOI
Enhancing Neoadjuvant Virotherapy’s Effectiveness by Targeting Stroma to Improve Resectability in Pancreatic Cancer (2024) DOI
Rescue of Methionine Dependence by Cobalamin in a Human Colorectal Cancer Cell Line (2024) DOI
Modulation of Hematopoietic Injury by a Promising Radioprotector, Gamma-Tocotrienol, in Rhesus Macaques Exposed to Partial-Body Radiation (2023) DOI
Climate Change and New Challenges for Rural Communities: Particulate Matter Matters (2023) DOI
Resveratrol induces major histocompatibility complex class I antigen presentation in a STING-dependent and independent manner in melanoma (2023) DOI
Increased Response to Immune Checkpoint Inhibitors with Dietary Methionine Restriction in a Colorectal Cancer Model (2023) DOI
Characterization of methionine dependence in melanoma cells (2023) DOI
Increased response to immune checkpoint inhibitors with dietary methionine restriction (2023) DOI
Characterization of methionine dependence in melanoma cells (2023) DOI

Federal Grants 1 $153,000 total

NIH/NIH Office of the Director Contact PI Aug 2025 - Jul 2027

Methionine metabolism in the acute response to radiation in the gut

NIH Office of the Director $153,000 R21

Grants & Funding

Team Leader for the Radiation Effects Team National Space Biomedical Research Institute - Pass Through: Baylor College of Medicine Co-Investigator
Synergizing methionine restriction with radiation therapy in KRAS mutant rectal cancer UAMS Cancer Institute Team Award Co-Investigator
Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
Methionine restriction as an adjuvant therapy in melanoma NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of Arkansas at Fayetteville Principal Investigator
Methionine metabolism in the acute response to radiation in the gut NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
Decreasing methionine intake to improve survival in patients with metastatic melanoma UAMS CTSA Other
Methionine metabolism in the acute response to radiation in the gut NIH/Nat. Inst. of Allergy & Infectious Diseases Principal Investigator
Methionine and autophagy in metastatic melanoma Barton Endowment, UAMS college of Medicine Principle Investigator