Shengyu Mu Institution Verified

Sourced from institutional research profiles (UAMS TRI or ARA).

Federal Grant PI

Researcher

University of Arkansas for Medical Sciences

faculty

17 h-index 99 pubs 1,405 cited

Research Areas

Blood Pressure and Hypertension Studies Immune Response and Inflammation T-cell and B-cell Immunology Pharmacological Effects and Toxicity Studies Cardiovascular Function and Risk Factors Phytochemicals and Antioxidant Activities Immune Cell Function and Interaction

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Shengyu Mu's research investigates the complex interplay of the immune system, cellular processes, and cardiovascular function, with a particular focus on hypertension and related inflammatory mechanisms. His work has explored how pathways involving Interferon-gamma (IFNγ) and PD-L1 can influence T-cell interactions and contribute to elevated blood pressure. Mu has also examined the role of specific cellular transitions, such as macrophage-to-myofibroblast transition, in the context of kidney injury and fibrosis, and investigated the potential of pharmacological interventions like eplerenone to mitigate these processes.

Further research by Mu has delved into the mechanisms underlying drug-induced conditions, including lymphedema, and explored potential therapeutic strategies. His work also encompasses the study of natural compounds, such as blueberry polyphenols, and their effects on oxidative stress and inflammatory signaling in human aortic endothelial cells, highlighting their potential role in cardiovascular health. Mu has received federal funding from the NIH/National Heart Lung and Blood Institute for his research on how T-cell homing to the kidney impacts salt retention and blood pressure regulation. His collaborations include extensive work with researchers at the University of Arkansas for Medical Sciences, such as Christoph Mora and Katherine Deck.

Metrics

  • h-index: 17
  • Publications: 99
  • Citations: 1,405

Selected Publications

  • Uncovering immune pathways for therapeutic targeting of hypertension (2025) DOI
  • Immune Dysregulation Connecting Type 2 Diabetes and Cardiovascular Complications (2025) DOI
  • Cytokine-induced Macrophage Transition Drives Cardiac Fibrosis and Diastolic Dysfunction (2025) DOI
  • Establishment of resident memory T cells anchors hypertension in the kidney (2025) DOI
  • Rhythmic Contractions of Lymph Vessels and Lymph Flow Are Disrupted in Hypertensive Rats (2024) DOI
  • T Cells Drive Kidney Memory for Hypertension (2024) DOI
  • Abstract P200: Immune memory contributes to chronic hypertension recurrence (2024) DOI
  • Abstract P335: An innate immune component in hypertension-induced cardiac dysfunction Christoph Mora, Katherine Deck, Yunmeng Liu, Lance Benson, Tonya Rafferty, & Shengyu Mu (2024) DOI
  • P227 MACROPHAGE TO MYOFIBROBLAST TRANSITION IN THE DEVELOPMENT OF DIASTOLIC DYSFUNCTION (2024) DOI
  • O14 KIDNEY RESIDENT MEMORY T CELLS MEDIATE THE CHRONIC PROGRESSION OF HYPERTENSION (2024) DOI
  • Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024) DOI
  • Metabolically active neutrophils represent a permissive niche for Mycobacterium tuberculosis (2024) DOI
  • Kidney resident memory CD8 T cells mediate recurrence of salt-sensitive hypertension (2024) DOI
  • Macrophage to Myofibroblast Transition Promotes Hypertension-Induced Cardiac Diastolic Dysfunction (2024) DOI
  • Eplerenone reduces lymphangiogenesis in the contralateral kidneys of UUO rats (2024) DOI

Federal Grants 1 $761,943 total

NIH/National Heart Lung and Blood Institute Contact PI Apr 2019 - Mar 2029

T cell homing to the kidney contributes to salt retention and blood pressure regulation

National Heart Lung and Blood Institute $761,943 R01

Grants & Funding

Collaborators

Researchers in the database who share publications

Christoph Mora University of Arkansas for Medical Sciences 24 shared publications Katherine Deck University of Arkansas for Medical Sciences 23 shared publications Yunping Guo University of Arkansas for Medical Sciences 16 shared publications Tonya Rafferty University of Arkansas for Medical Sciences 9 shared publications Yunmeng Liu University of Arkansas for Medical Sciences 8 shared publications Nancy Rusch University of Arkansas for Medical Sciences 6 shared publications Pamela I. Rogers University of Arkansas for Medical Sciences 4 shared publications Shuoqiu Deng University of Arkansas for Medical Sciences 4 shared publications

Similar Researchers

Based on overlapping research topics

Katherine Deck University of Arkansas for Medical Sciences
Blood Pressure and Hypertension Studies Immune Response and Inflammation T-cell and B-cell Immunology
Strong match 5 shared topics
Yunping Guo University of Arkansas for Medical Sciences
Blood Pressure and Hypertension Studies Immune Response and Inflammation T-cell and B-cell Immunology
Strong match 5 shared topics
Ana Clara P. Azevedo‐Pouly University of Arkansas for Medical Sciences
Immune Response and Inflammation T-cell and B-cell Immunology Pharmacological Effects and Toxicity Studies
Good match 4 shared topics
Lin-Xi Li University of Arkansas for Medical Sciences
Immune Response and Inflammation T-cell and B-cell Immunology Cardiovascular Function and Risk Factors
Good match 4 shared topics
Yunmeng Liu University of Arkansas for Medical Sciences
Immune Response and Inflammation T-cell and B-cell Immunology Cardiovascular Function and Risk Factors
Good match 4 shared topics
Christoph Mora University of Arkansas for Medical Sciences
Blood Pressure and Hypertension Studies Immune Response and Inflammation Cardiovascular Function and Risk Factors
Good match 4 shared topics