Qiangen Wu Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

21 h-index 62 pubs 1,086 cited

Research Areas

Pharmacological Effects and Toxicity Studies Cannabis and Cannabinoid Research Carcinogens and Genotoxicity Assessment Drug-Induced Hepatotoxicity and Protection Tracheal and airway disorders Metabolism and Genetic Disorders Molecular Biology Techniques and Applications

Links

ORCID Research Group

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OverviewAI-generated summary

Qiangen Wu's research focuses on evaluating the toxicity of various chemical substances and their metabolites using in vitro models. Wu has investigated the effects of cannabidiol and its metabolites on both mouse and human cells, including Sertoli and Leydig cells, and has explored its metabolism and liver toxicity. This work has been published in journals such as Toxicology and Applied Pharmacology and Frontiers in Pharmacology.

Further research by Wu has examined the toxicity of airborne chemicals in human airway tissue models. This includes studies on formaldehyde fumes, glutaraldehyde aerosols, and ortho-phthalaldehyde aerosols. Wu also investigates the characterization of cytochrome P450 (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity. Wu leads a research group and collaborates with several researchers at the National Center for Toxicological Research, including Matthew Bryant and Xuefei Cao, with whom Wu has co-authored five publications.

Metrics

h-index: 21
Publications: 62
Citations: 1,086

Selected Publications

Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025) DOI
Retraction notice to “On the in vivo early toxic properties of Aβ25–35 peptide in the rat hippocampus: Involvement of the Receptor-for-Advanced Glycation-End-Products and changes in gene expression” [Neurotoxicology and Teratology 33 (2011) 288–296] (2025) DOI
7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025) DOI
Retraction notice to “On the early toxic effect of quinolinic acid: Involvement of RAGE” [Neurosci. Lett. 474(2) (2010) 74–78] (2024) DOI
Pharmacokinetic analysis of nicotine and its metabolites (cotinine and <i>trans</i>-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024) DOI
Investigation of cannabidiol-induced cytotoxicity in human hepatic cells (2024) DOI
Metabolism and liver toxicity of cannabidiol (2024) DOI
Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024) DOI
The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024) DOI
Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024) DOI
Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model (2022) DOI
Evaluating the Sub-Acute Toxicity of Formaldehyde Fumes in an In Vitro Human Airway Epithelial Tissue Model (2022) DOI
In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells (2021) DOI
Integration of transcriptome analysis with pathophysiological endpoints to evaluate cigarette smoke toxicity in an in vitro human airway tissue model (2021) DOI
Transcriptome analysis reveals lung-specific miRNAs associated with impaired mucociliary clearance induced by cigarette smoke in an in vitro human airway tissue model (2021) DOI