Charity L. Washam

Researcher

University of Arkansas for Medical Sciences

faculty

14 h-index 54 pubs 1,065 cited

Research Areas

Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks Immune Response and Inflammation Cancer-related molecular mechanisms research Metabolomics and Mass Spectrometry Studies Microbial infections and disease research Protein Structure and Dynamics

Links

ORCID Research Group

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OverviewAI-generated summary

Charity L. Washam's research focuses on the application of multi-omics data integration and molecular biology techniques to understand complex biological processes and diseases. Her work includes the development of computational tools for quantitative proteomics, such as the proteoDA package. Washam has investigated the cellular heterogeneity and transcriptomic profiling in mouse models of Leishmania major infection, exploring the impact of HIF-α activation on macrophage function. Her publications also address the molecular mechanisms underlying diseases like triple-negative breast cancer and multiple myeloma, identifying potential therapeutic targets. Additionally, she has explored non-invasive methods for cancer screening, such as proteomic profiling of tear fluid for colon cancer detection. Washam has a history of collaboration with researchers at the University of Arkansas for Medical Sciences, including Dr. Stephanie Byrum, Duah Alkam, Allen Gies, and Samuel G. Mackintosh.

Metrics

h-index: 14
Publications: 54
Citations: 1,065

Selected Publications

Rescue of Angiopoietin‐2 Inhibits Proliferation of Lymphatic Malformation Endothelial Cells (2025) DOI
Guanylate-Binding Proteins Promote Host Defense Against <i>Leishmania major</i> by Balancing iNOS/Arg-1 in Myeloid Cells (2025) DOI
HIF-α signaling regulates the macrophage inflammatory response during Leishmania major infection (2025) DOI
Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024) DOI
HIF-α signaling regulates the macrophage inflammatory response during <i>Leishmania major</i> infection (2024) DOI
One-pot method for preparing DNA, RNA, and protein for multiomics analysis (2024) DOI
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023) DOI
Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy (2023) DOI
Repurposing live attenuated trivalent MMR vaccine as cost-effective cancer immunotherapy (2022) DOI
In vivo transcriptional analysis of mice infected with Leishmania major unveils cellular heterogeneity and altered transcriptomic profiling at single-cell resolution (2022) DOI
Proteogenomics Reference Database Protocol v1 (2022) DOI
Proteogenomics Reference Database Protocol v1 (2022) DOI
Proteomic profiling of tear fluid as a promising non-invasive screening test for colon cancer (2022) DOI
Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy (2022) DOI
HIF-α Activation Impacts Macrophage Function during Murine Leishmania major Infection (2021) DOI