Lijun Ren Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

24 h-index 87 pubs 1,800 cited

Research Areas

Immune Response and Inflammation Pharmacological Effects and Toxicity Studies Diet and metabolism studies SARS-CoV-2 and COVID-19 Research Molecular Biology Techniques and Applications Plant Physiology and Cultivation Studies Health Policy Implementation Science Drug-Induced Hepatotoxicity and Protection

Links

ORCID Research Group

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OverviewAI-generated summary

Lijun Ren's research investigates the molecular mechanisms underlying various biological processes and disease states. A significant portion of this work focuses on the role of specific proteins and signaling pathways in cellular functions, such as metabolism and inflammation. For instance, studies have explored how Pyruvate Kinase M2 influences glycolysis and keratinocyte proliferation in the context of psoriasis, and how celastrol alleviates oxidative stress induced by multi-walled carbon nanotubes via the Keap1/Nrf2/HO-1 pathway.

Further research extends to the development and application of advanced in vitro models for studying disease and drug toxicity. This includes the co-culture of human primary hepatocytes and nonparenchymal liver cells in a liver-chip model to investigate drug-induced liver injury. Additionally, Ren's work has touched upon environmental science and public health, including the analysis of environmental management strategies in response to COVID-19 and stakeholder views on plastic restriction policies in China, employing text mining techniques. The researcher also has a publication exploring the regulation of synapsis and recombination in rice meiosis.

Ren leads a research group and has established collaborations with several colleagues at the National Center for Toxicological Research, including Katy S Papineau and Laura K. Schnackenberg, with whom they share multiple publications. Ren's scholarly output is marked by a h-index of 24 and over 1,800 citations across 87 publications, designating them as a highly cited researcher.

Metrics

h-index: 24
Publications: 87
Citations: 1,800

Selected Publications

Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025) DOI
Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025) DOI
Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025) DOI
Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024) DOI
Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022) DOI