William B. Mattes Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Senior Scientific Advisor

National Center for Toxicological Research

faculty

33 h-index 100 pubs 3,822 cited

Research Areas

Metabolomics and Mass Spectrometry Studies Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Drug-Induced Hepatotoxicity and Protection Cardiac Function and Risk Factors Cancer Treatment and Pharmacology Biomarkers

Links

ORCID Lab Website

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OverviewAI-generated summary

William B. Mattes' research focuses on the application of metabolomics and in vitro human-based models for toxicity screening and drug development. He investigates how various compounds, including oncology drugs and acrylamide, impact cellular function, particularly mitochondrial health and cell death in primary human hepatocytes. His work explores the use of multi-component biomarkers and induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) for predicting drug-induced toxicity, such as cardiotoxicity and liver mitochondrial dysfunction.

Mattes has published extensively on these topics, with recent work validating cardiac non-animal methods (NAMs) for toxicity screening and developing kinetic and organ toxicity data using novel in vitro multiple organ platforms. His scholarship metrics include an h-index of 33, with over 100 publications and 3,822 citations, designating him as a highly cited researcher. He collaborates with several colleagues at the National Center for Toxicological Research, including Li Pang, Katy S Papineau, Lijun Ren, and Laura K. Schnackenberg, with whom he shares multiple publications.

Metrics

  • h-index: 33
  • Publications: 100
  • Citations: 3,822

Selected Publications

  • Validating and Using Cardiac NAMs for Toxicity Screening and Drug Development (2025) DOI
  • Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025) DOI
  • Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024) DOI
  • Metabolomics as a Truly Translational Tool for Precision Medicine (2021) DOI

Collaborators

Researchers in the database who share publications

Li Pang National Center for Toxicological Research 3 shared publications Katy S Papineau National Center for Toxicological Research 2 shared publications Lijun Ren National Center for Toxicological Research 2 shared publications Laura K. Schnackenberg National Center for Toxicological Research 2 shared publications Vikrant Vijay National Center for Toxicological Research 1 shared publication Chengzhong Cai National Center for Toxicological Research 1 shared publication Prathyusha Bagam National Center for Toxicological Research 1 shared publication Qiang Shi National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Laura K. Schnackenberg National Center for Toxicological Research
Metabolomics and Mass Spectrometry Studies Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology
Good match 5 shared topics
Li Pang National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Drug-Induced Hepatotoxicity and Protection
Good match 4 shared topics
Kate Steed University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Cancer Treatment and Pharmacology
Good match 3 shared topics
J.C. Hsu University of Arkansas for Medical Sciences
Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Cancer Treatment and Pharmacology
Good match 3 shared topics
Katy S Papineau National Center for Toxicological Research
Pharmacological Effects and Toxicity Studies Mitochondrial Function and Pathology Drug-Induced Hepatotoxicity and Protection
Good match 3 shared topics
Grover Miller University of Arkansas for Medical Sciences
Metabolomics and Mass Spectrometry Studies Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection
Good match 3 shared topics