Qiang Shi Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Senior Staff Fellow

National Center for Toxicological Research

staff

36 h-index 224 pubs 16,738 cited

Research Areas

Epigenetics and DNA Methylation Protein Structure and Dynamics Ubiquitin and proteasome pathways Neuroinflammation and Neurodegeneration Mechanisms Dementia and Cognitive Impairment Research Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Phytochemicals and Antioxidant Activities

Links

ORCID Lab Website

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OverviewAI-generated summary

Qiang Shi's research focuses on understanding molecular mechanisms related to ubiquitination and deubiquitination, particularly within the context of nucleosomes and their role in cellular processes. He has investigated the structural and mechanistic basis for nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A. Additionally, his work has explored the deubiquitination of H2AK119 by the deubiquitinase USP16 and the selective recognition of H2AK119Ub nucleosomes by the Synovial sarcoma X breakpoint 1 protein.

Shi's research also extends to the study of ferroptosis and its connection to Alzheimer's disease. He has contributed to the development of tools for biomarker identification, such as DNAzyme-based probing and pulldown methods for low-abundance candidates. His work includes investigating the protective effects of combined nicotinamide mononucleotide and lycopene against cognitive impairment and oxidative damage in aging models, mediated via the Keap1-Nrf2 signaling pathway.

Further research by Shi involves the use of in vitro models to study drug-induced liver injury, specifically employing a co-culture system of human primary hepatocytes and nonparenchymal liver cells within the Emulate® Liver-Chip. With a career marked by significant publication and citation counts (h-index: 36, total publications: 224, total citations: 16,738), Shi is recognized as a highly cited researcher.

Metrics

  • h-index: 36
  • Publications: 224
  • Citations: 16,738

Selected Publications

  • Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025) DOI
  • Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application (2023) DOI
  • Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022) DOI
  • Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021) DOI

Collaborators

Researchers in the database who share publications

Katy S Papineau National Center for Toxicological Research 2 shared publications Lijun Ren National Center for Toxicological Research 2 shared publications Laura K. Schnackenberg National Center for Toxicological Research 2 shared publications Binsheng Gong National Center for Toxicological Research 1 shared publication Joshua Xu National Center for Toxicological Research 1 shared publication Dan Li National Center for Toxicological Research 1 shared publication Xiaobo He National Center for Toxicological Research 1 shared publication Qingsu Xia National Center for Toxicological Research 1 shared publication

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