Stephanie D. Byrum

High Impact

Researcher

UAMS

faculty

33 h-index 284 pubs 4,254 cited

Research Areas

Cancer-related molecular mechanisms research Protein Degradation and Inhibitors Epigenetics and DNA Methylation Genomics and Chromatin Dynamics Cancer Treatment and Pharmacology Molecular Biology Techniques and Applications Bioinformatics and Genomic Networks

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Dr. Stephanie Byrum's research centers on understanding the molecular mechanisms underlying cancer development and exploring novel therapeutic strategies. Her work has investigated the role of phase separation in driving aberrant chromatin looping and contributing to cancer progression. Dr. Byrum has also focused on developing targeted cancer therapies, including PROTAC (proteolysis-targeting chimera) degraders, with publications detailing the suppression of oncogenic nodes through NSD3-targeted PROTACs and the discovery of dual WDR5 and Ikaros PROTAC degraders as potential anti-cancer agents.

Further research interests include the regulation of signal-induced transcription by CDK8 and CDK19, and the mechanisms by which TNRC18 mediates the silencing of endogenous retrotransposons through H3K9me3 engagement. Dr. Byrum has also utilized cistrome analysis to uncover regulatory axes in tumorigenesis, specifically focusing on the YY1:BRD2/4-PFKP axis in advanced prostate cancer. Her work also extends to the development of computational tools, as evidenced by the package proteoDA for quantitative proteomics.

Dr. Byrum collaborates extensively with researchers at the University of Arkansas for Medical Sciences, including Samuel G. Mackintosh, Alan J. Tackett, Charity L. Washam, and Aaron J. Storey, with whom she shares numerous publications. Her scholarship metrics include an h-index of 33, over 283 total publications, and more than 4,209 citations, marking her as a highly cited researcher.

Metrics

h-index: 33
Publications: 284
Citations: 4,254

Selected Publications

The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators (2025) DOI
Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis (2025) DOI
An <i>ex vivo</i> human precision-cut lung slice platform provides insight into SARS-CoV-2 pathogenesis and antiviral drug efficacy (2024) DOI
One-pot method for preparing DNA, RNA, and protein for multiomics analysis (2024) DOI
Anterior Pituitary Transcriptomics Following a High-Fat Diet: Impact of Oxidative Stress on Cell Metabolism (2023) DOI
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons (2023) DOI
Antiviral responses in a Jamaican fruit bat intestinal organoid model of SARS-CoV-2 infection (2023) DOI
Characterization of methionine dependence in melanoma cells (2023) DOI
Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023) DOI
Musashi Exerts Control of Gonadotrope Target mRNA Translation During the Mouse Estrous Cycle (2023) DOI
Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels (2023) DOI
CDK8 and CDK19: positive regulators of signal-induced transcription and negative regulators of Mediator complex proteins (2023) DOI
PCSK9 attenuates efferocytosis in endothelial cells and promotes vascular aging (2023) DOI
Expression of integrin β-7 is epigenetically enhanced in multiple myeloma subgroups with high-risk cytogenetics (2023) DOI
Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue (2023) DOI