Javier R. Revollo Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Research Biologist

National Center for Toxicological Research

faculty

15 h-index 50 pubs 3,330 cited

Research Areas

Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Carcinogens and Genotoxicity Assessment Antibiotic Resistance in Bacteria Bioinformatics and Genomic Networks CRISPR and Genetic Engineering

Links

ORCID

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OverviewAI-generated summary

Javier R. Revollo's research focuses on evaluating the mutagenic effects of various substances using advanced sequencing technologies. His work has investigated the mutagenicity of compounds like Molnupiravir, N4-hydroxycytidine, and N-nitrosodimethylamine in both bacterial and mammalian cell systems, including 2D and 3D HepaRG cell cultures. Revollo has utilized PacBio and HiFi sequencing to detect genome-wide, ultra-low-frequency substitution mutations resulting from exposure to chemical mutagens and to assess in vivo chemical mutagenesis. His publications also address the unbiased detection of ultrarare off-target mutations in genome-edited cell populations and the analysis of antibiotic resistance, virulence, and plasmid dynamics in multidrug-resistant E. coli isolates. Revollo has published 50 papers, accumulating over 3,330 citations and an h-index of 15. He collaborates with researchers such as Jaime A. Miranda, Page B. McKinzie, Vasily N. Dobrovolsky, and Robert H. Heflich, primarily from the National Center for Toxicological Research.

Metrics

h-index: 15
Publications: 50
Citations: 3,330

Selected Publications

Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025) DOI
Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025) DOI
Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection (2024) DOI
Assessment of in vivo chemical mutagenesis by long-read sequencing (2024) DOI
Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp (2024) DOI
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024) DOI
Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023) DOI
Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023) DOI
Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp (2023) DOI
Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing (2022) DOI
Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022) DOI
Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022) DOI
Draft Genome Sequences of Tetracycline-Resistant Shiga Toxin-Producing Escherichia coli Isolates from Food (2022) DOI
Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022) DOI
<scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens (2021) DOI