Rebecca Wynne Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Researcher

National Center for Toxicological Research

faculty

19 h-index 30 pubs 1,427 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection Tracheal and airway disorders Cancer-related molecular mechanisms research Molecular Biology Techniques and Applications

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Research Group

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OverviewAI-generated summary

Rebecca Wynne's research focuses on assessing the toxicity of various substances using human in vitro models, particularly organotypic airway cultures. Her work investigates genetic toxicity, evaluating DNA damage and mutagenesis with methods like the CometChip and Duplex Sequencing. Wynne has studied the subacute pulmonary toxicity of glutaraldehyde and ortho-phthalaldehyde aerosols in human airway tissue models. Her research also extends to the mechanisms of chemical-induced carcinogenesis, including the role of alcohol consumption in promoting diethylnitrosamine-induced hepatocarcinogenesis in mice through the Wnt/β-Catenin signaling pathway. Wynne collaborates with researchers from the National Center for Toxicological Research, including Kelly E. Mercer and Xuefei Cao, and from the University of Arkansas for Medical Sciences, such as Thomas M. Badger. She has published 30 papers, accumulating 1,427 citations, with an h-index of 19.

Metrics

  • h-index: 19
  • Publications: 30
  • Citations: 1,427

Selected Publications

  • Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
  • Subacute Pulmonary Toxicity of Glutaraldehyde Aerosols in a Human In Vitro Airway Tissue Model (2022) DOI
  • Genetic toxicity testing using human in vitro organotypic airway cultures: Assessing <scp>DNA</scp> damage with the <scp>CometChip</scp> and mutagenesis by Duplex Sequencing (2021) DOI
  • Toxicity of Ortho-phthalaldehyde Aerosols in a Human <i>In Vitro</i> Airway Tissue Model (2021) DOI

Collaborators

Researchers in the database who share publications

Thomas M. Badger University of Arkansas for Medical Sciences 6 shared publications Kelly E. Mercer National Center for Toxicological Research 6 shared publications Xuefei Cao National Center for Toxicological Research 4 shared publications Roberta A. Mittelstaedt National Center for Toxicological Research 2 shared publications Robert H. Heflich National Center for Toxicological Research 2 shared publications Qiangen Wu National Center for Toxicological Research 2 shared publications Nan Mei National Center for Toxicological Research 1 shared publication Barbara L. Parsons National Center for Toxicological Research 1 shared publication

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