Darin E. Jones

High Impact

Associate Professor

University of Arkansas for Medical Sciences

faculty

Pharmaceutical Science, College of Pharmacy

23 h-index 86 pubs 1,229 cited

Research Areas

DNA Repair Mechanisms Protein Structure and Dynamics Computational Drug Discovery Methods SARS-CoV-2 and COVID-19 Research Cancer Treatment and Pharmacology Phytochemicals and Antioxidant Activities Molecular Biology Techniques and Applications

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Darin E. Jones's research focuses on understanding and developing inhibitors for enzymes involved in nucleic acid metabolism and repair, with applications in cancer therapy and antiviral development. His work investigates mechanisms of DNA repair, including homology-directed repair, and explores potential therapeutic targets within these pathways. Jones has published research on the structure and inhibition of key enzymes such as Polθ and uracil-DNA glycosylase, aiming to disrupt their function in disease contexts.

His laboratory also investigates the role of specific proteins in cellular processes like DNA repair initiation. Furthermore, Jones's research has explored radioprotective effects of compounds like tocotrienols, examining their antioxidant and signaling mechanisms. He has also employed advanced screening methods, including time-resolved X-ray scattering and HT-SAXS, to identify and develop chemical probes and allosteric inhibitors for enzyme targets, including those relevant to SARS-CoV-2. Jones leads a research group at the University of Arkansas for Medical Sciences and has collaborated with researchers including Philip J. Breen and Edward J. Selvik.

Metrics

  • h-index: 23
  • Publications: 86
  • Citations: 1,229

Selected Publications

  • Structural basis for substrate-assisted catalysis and small-molecule inhibition of alphavirus macrodomains (2026) DOI
  • EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025) DOI
  • Chemical screening by time-resolved X-ray scattering to discover allosteric probes (2024) DOI
  • Tocotrienols Provide Radioprotection to Multiple Organ Systems through Complementary Mechanisms of Antioxidant and Signaling Effects (2023) DOI
  • Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity (2023) DOI
  • 466 Development of a novel tocotrienol analogue, tocoflexol, as a radiomitigator (2023) DOI
  • Applying HT-SAXS to chemical ligand screening (2022) DOI
  • Analysis of Plant–Plant Interactions Reveals the Presence of Potent Antileukemic Compounds (2022) DOI
  • An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2 (2021) DOI
  • GRB2 enforces homology-directed repair initiation by MRE11 (2021) DOI
  • An effective human uracil-DNA glycosylase inhibitor targets the open pre-catalytic active site conformation (2021) DOI
  • Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors (2021) DOI

Grants & Funding

  • Pharmacological Modulation of Poly (ADP-ribose) Metabolism NIH/Nat. Cancer Institute - Pass Through: University of Texas Health Science Center at Houston Principal Investigator
  • A Plug and Play DOE Approach for Emerging Threats: Taskforce 5 US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory Principal Investigator
  • Cellular Functions of Eukaryotic DNA Ligases - Continuation NIH/Nat. Inst. of General Medical Sciences - Pass Through: University of New Mexico Principal Investigator
  • PHARMACOLOGICAL MODULATION OF POLY(ADP-RIBOSE) METABOLISM NIH Co-Principal Investigator
  • Targeting DNA ligase 1 in Ovarian Cancer NIH/Nat. Cancer Institute - Pass Through: University of New Mexico Principal Investigator
  • A Plug and Play DOE Approach for Emerging Threats: Taskforce 5 US Department of Energy - Pass Through: Lawrence Berkeley National Laboratory Principal Investigator
  • Structural Cell Biology of DNA Repair Machines Project 3 - PARP: PAR-dependent, phase-transitioned protein assemblies, and DNA repair. NIH/Nat. Cancer Institute - Pass Through: Lawrence Berkeley National Laboratory Principal Investigator
  • Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration - Pass Through: Arkansas Space Grant Consortium Principal Investigator

Collaborators

Researchers in the database who share publications

Philip J. Breen University of Arkansas for Medical Sciences 4 shared publications Edward J. Selvik University of Arkansas for Medical Sciences 3 shared publications Shobanbabu Bommagani University of Arkansas for Medical Sciences 2 shared publications David E. Mery University of Arkansas for Medical Sciences 2 shared publications Nükhet Aykin‐Burns University of Arkansas for Medical Sciences 2 shared publications Shivangi Shrimali National Center for Toxicological Research 2 shared publications Abdul H. Khan University of Arkansas for Medical Sciences 1 shared publication Abhishek Mishra University of Arkansas for Medical Sciences 1 shared publication

Similar Researchers

Based on overlapping research topics

Edward J. Selvik University of Arkansas for Medical Sciences
DNA Repair Mechanisms Protein Structure and Dynamics Cancer Treatment and Pharmacology
Good match 5 shared topics
Dylan S. Ogden University of Arkansas at Fayetteville
Protein Structure and Dynamics Computational Drug Discovery Methods SARS-CoV-2 and COVID-19 Research
Good match 4 shared topics
Sures Thallapuranam University of Arkansas at Fayetteville
Protein Structure and Dynamics Computational Drug Discovery Methods SARS-CoV-2 and COVID-19 Research
Good match 4 shared topics
James Losey University of Arkansas at Fayetteville
Protein Structure and Dynamics Computational Drug Discovery Methods SARS-CoV-2 and COVID-19 Research
Good match 4 shared topics
Adithya Polasa University of Arkansas at Fayetteville
Protein Structure and Dynamics Computational Drug Discovery Methods SARS-CoV-2 and COVID-19 Research
Good match 4 shared topics
Fauzia Haque University of Arkansas at Fayetteville
Protein Structure and Dynamics Computational Drug Discovery Methods SARS-CoV-2 and COVID-19 Research
Good match 4 shared topics