Samuel G. Mackintosh

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

Biochemistry & Molecular Biology, College of Medicine

36 h-index 139 pubs 4,389 cited

Research Areas

Cancer-related molecular mechanisms research Protein Degradation and Inhibitors Genomics and Chromatin Dynamics Mitochondrial Function and Pathology Bone health and treatments Cancer Treatment and Pharmacology Molecular Biology Techniques and Applications

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Samuel G. Mackintosh, Professor in Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences, leads a research group focused on understanding molecular mechanisms underlying disease, particularly cancer. His work investigates how cellular processes, such as chromatin dynamics and protein degradation, contribute to tumorigenesis and how these can be targeted for therapeutic intervention. Recent publications highlight his group's efforts in exploring novel anti-cancer strategies, including the development of PROTAC degraders targeting specific oncogenic proteins like NSD3 and WDR5, as well as Ikaros. His research also delves into the role of iron uptake via the transferrin receptor 1 in regulating bone mass, involving osteoclast mitochondria and cytoskeleton. Mackintosh's scholarship metrics include an h-index of 36, with 139 total publications and 4,389 citations, recognizing him as a highly cited researcher.

His collaborative network within the University of Arkansas for Medical Sciences is extensive, with significant publication counts shared with key collaborators Alan J. Tackett (23 shared publications), Aaron J. Storey (19 shared publications), Dr. Stephanie Byrum (18 shared publications), and Rick D. Edmondson (12 shared publications). This demonstrates a strong, interconnected research environment focused on advancing biomedical science.

Metrics

h-index: 36
Publications: 139
Citations: 4,389

Selected Publications

277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025) DOI
Multicellular tumor-stromal interactions recapitulate aspects of therapeutic response and human oncogenic signaling in a 3D disease model for H3K27M-altered DIPG (2025) DOI
BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication (2025) DOI
Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis (2025) DOI
The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators (2025) DOI
Staphylococcus aureus Proteins Implicated in the Reduced Virulence of sarA and sarA/agr Mutants in Osteomyelitis (2025) DOI
Dynamic global acetylation remodeling during the yeast heat shock response (2025) DOI
Cold Storage Disrupts the Proteome and Phosphoproteome Landscape in Rat Kidney Transplants (2024) DOI
Quantitative analysis of septin Cdc10 & Cdc3-associated proteome during stress response in the fungal pathogen Cryptococcus neoformans (2024) DOI
319 Comprehensive analysis of proteome turnover dynamics during T cell exhaustion (2024) DOI
Quantitative plasma proteomic analysis in children after superior cavopulmonary anastomosis with pulmonary arteriovenous malformations (2024) DOI
Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways (2024) DOI
Chromatin targeting of the RNF12/RLIM E3 ubiquitin ligase controls transcriptional responses (2024) DOI
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons (2023) DOI
304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors (2023) DOI

Grants & Funding

HCV NS3: Biological, Biochemical and Structural Analysis NIH Co-Investigator
Single molecule nucleic acid enzymology NIH Co-Investigator
Orbitrap Fusion Tribrid Mass Spectrometer NIH Principal Investigator
Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH/Office of the Director Principal Investigator
Q Exactive HF-X Hybrid Quadrupole Orbitrap Mass Spectrometer NIH Principal Investigator
IDeA National Resource for Quantitative Proteomics NIH Co-Investigator